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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

机译：遗传额颞叶痴呆倡议（GENFI）研究中遗传额颞叶痴呆的症状前认知和神经解剖学变化：横断面分析

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摘要

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies of other genetic dementias have shown neuroimaging and cognitive changes before symptoms onset, and we aimed to identify whether such changes could be shown in frontotemporal dementia.

机译：额颞痴呆是一种高度可遗传的神经退行性疾病。在大约三分之一的患者中，该疾病是由常染色体显性遗传突变引起的，通常是以下三个基因之一：颗粒蛋白（GRN），微管相关蛋白tau（MAPT）或9号染色体开放阅读框72（C9orf72）。从其他遗传性痴呆症的研究中发现，在症状发作之前神经影像和认知功能发生了改变，我们旨在确定这种改变是否可以在额颞痴呆症中显示。

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Rohrer, Jonathan D; Nicholas, Jennifer M; Cash, David M; van Swieten, John; Dopper, Elise; Jiskoot, Lize; van Minkelen, Rick; Rombouts, Serge A; Cardoso, M Jorge; Clegg, Shona; Espak, Miklos; Mead, Simon; Thomas, David L; De Vita, Enrico; Masellis, Mario; Black, Sandra E; Freedman, Morris; Keren, Ron; MacIntosh, Bradley J; Rogaeva, Ekaterina; Tang-Wai, David; Tartaglia, Maria Carmela; Laforce, Robert (Jr); Tagliavini, Fabrizio; Tiraboschi, Pietro; Redaelli, Veronica; Prioni, Sara; Grisoli, Marina; Borroni, Barbara; Padovani, Alessandro; Galimberti, Daniela; Scarpini, Elio; Arighi, Andrea; Fumagalli, Giorgio; Rowe, James B; Coyle-Gilchrist, Ian; Graff, Caroline; Fallström, Marie; Jelic, Vesna; Ståhlbom, Anne Kinhult; Andersson, Christin; Thonberg, Håkan; Lilius, Lena; Frisoni, Giovanni; Pievani, Michela; Bocchetta, Martina; Benussi, Luisa; Ghidoni, Roberta; Finger, Elizabeth; Sorbi, Sandro; Nacmias, Benedetta; Lombardi, Gemma; Polito, Cristina; Warren, Jason D; Ourselin, Sebastien; Fox, Nick C; Rossor, Martin N;
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1. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis [J] . Rohrer Jonathan D., Nicholas Jennifer M., Cash David M., Lancet Neurology . 2015,第3期

机译：遗传额颞叶痴呆倡议（GENFI）研究中遗传额颞叶痴呆的症状前认知和神经解剖学变化：横断面分析
2. Presymptomatic cerebral perfusion biomarker changes in genetic frontotemporal dementia: results from the GENetic Frontotemporal dementia Initiative (GENFI) [J] . Mutsaerts H., Mirza S. S., Rohrer J., Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2016,第Suppla1期

机译：基因前额颞叶痴呆的症状前脑灌注生物标志物变化：基因前额颞叶痴呆倡议（GENFI）的结果
3. Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study [J] . Mutsaerts Henri J. M. M., Mirza Saira S., Petr Jan, Brain: A journal of neurology . 2019,第Pta4期

机译：脑灌注变化在假设遗传学型颞蛋白痴呆症：一种Genfi研究
4. A Genetic Algorithm Optimized Artificial Neural Network for the Segmentation of MR Images in Frontotemporal Dementia [C] . R. Sheela Kumari, Tinu Varghese, C. Kesavadas, International conference on swarm, evolutionary, and memetic computing . 2013

机译：遗传算法优化的人工神经网络分割额颞叶痴呆MR图像
5. Studying the Effect of Tdp-43 Proteinopathy on Frontotemporal Dementia-Related Behaviors in Drosophila melanogaster [D] . Dolbeck, Elizabeth. 2021

机译：研究TDP-43蛋白病对果蝇Melanogaster的终颞痴呆相关行为的影响
6. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis [O] . Jonathan D Rohrer, Jennifer M Nicholas, David M Cash, -1

机译：遗传额颞叶痴呆倡议（GENFI）研究中遗传额颞叶痴呆的症状前认知和神经解剖学变化：横断面分析
7. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: A cross-sectional analysis [O] . Rohrer, Jonathan D, Nicholas, Jennifer M, Cash, David M, 2015

机译：遗传额颞叶痴呆倡议（GENFI）研究中遗传额颞叶痴呆的症状前认知和神经解剖学变化：横断面分析

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

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